The story of Desperadas 2 is about four half-sisters - Isabella, Patricia, Stephanie, and Courtney - who have another big problems in their life. They also found out that they have another half-sister, Lugaluda.
Trisha spent about 20 years living and working in the US, while Gabo has been working in different jobs to make ends meet in the Philippines. The two will cross paths when Trish returns to the country.
Childhood friends Coby and Ava, who only see each other during summer vacations. As time passes, the characters develop feelings for each other but having a relationship long-distance is a great challenge for both.